IRX3基因对体重影响的可能机制：综述。
The possible mechanisms of the effects of IRX3 gene on body weight: an overview.
作者信息
Gholamalizadeh Maryam, Jarrahi Alirea Mosavi, Akbari Mohammad Esmail, Rezaei Shahla, Doaei Saeid, Mokhtari Zohreh, Torki Abbas
机构信息
Students' Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Arch Med Sci Atheroscler Dis. 2019 Aug 27;4:e225-e230. doi: 10.5114/amsad.2019.87545. eCollection 2019.
INTRODUCTION
Recent studies reported that FTO exert its effects on body weight through change the expression IRX3. The aim of this study was investigation of the possible mechanisms of the effects of IRX3 gene on obesity.
MATERIAL AND METHODS
The present review was carried out using keywords such as polymorphism and/or obesity and/or BMI and/or IRX3 gene and/or Iroquois homeobox protein 3. Databases including PubMed, Science Direct, web of sciences, Scopus, and Cochran databases were used to collect all related articles published from 2000 to 2019.
RESULTS
Based on this review, there are some evidences on the association between the IRX3 polymorphisms and the IRX3 expression level with body weight. In some studies, the up-regulation of IRX3 expression was related to increased body weight, while in some other studies down-regulation of IRX3 expression was related to obesity.
CONCLUSIONS
This review investigated the probable mechanisms of the effects of the IRX3 gene on obesity. Studies in this are limited and reported contradictory results. Further studies are required to evaluate the role of IRX3 gene in the associations between genes, diet, and obesity.
引言
最近的研究报道，FTO通过改变IRX3的表达对体重产生影响。本研究的目的是探究IRX3基因影响肥胖的可能机制。
材料与方法
本综述通过使用多态性和/或肥胖和/或BMI和/或IRX3基因和/或易洛魁同源框蛋白3等关键词进行。包括PubMed、Science Direct、科学网、Scopus和Cochran数据库在内的数据库被用于收集2000年至2019年发表的所有相关文章。
结果
基于本综述，有一些证据表明IRX3多态性和IRX3表达水平与体重之间存在关联。在一些研究中，IRX3表达上调与体重增加有关，而在其他一些研究中，IRX3表达下调与肥胖有关。
结论
本综述探究了IRX3基因影响肥胖的可能机制。该领域的研究有限且报道的结果相互矛盾。需要进一步的研究来评估IRX3基因在基因、饮食和肥胖之间关联中的作用。
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