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[晚期日本血吸虫病负担评估方法:一项比较研究]

[Approaches used for assessment of the burden of advanced schistosomiasis japonica: a comparative study].

作者信息

Yi-Ting Li, Xin-Ting Cai, Jin-Hua Zhu, Le-Ping Sun, Hai-Yong Hua, Li-Guang Tian, Ting Feng, Shi-Zhu Li, Guang-Hui Ren, Tie-Wu Jia

机构信息

National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, Shanghai 200025, China.

Hunan Institution of Schistosomiasis control, China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2019 Jun 12;31(3):280-284. doi: 10.16250/j.32.1374.2019079.

Abstract

OBJECTIVE

To compare the approaches used for the assessment of disability adjust life years (DALYs) for advanced schistosomiasis japonica, so as to provide scientific evidence for accurate assessment of the burden of advanced schistosomiasis japonica.

METHODS

The patients with advanced schistosomiasis japonica receiving treatment and assistance programs in Hunan Province in 2017 were enrolled, and the years lived with disability (YLD) for the patients with advanced schistosomiasis japonica was calculated using the common global burden of disease (GBD) estimation method, the modified GBD method with addition of common syndromes of advanced schistosomiasis japonica, and the quality of life assessment method.

RESULTS

The YLDs of patients with advanced schistosomiasis japonica, the mean YLDs per capita, and the percentages of YLD were 673.94, 728.77 person-years and 1 761.99 person-years; 0.181, 0.196 person-years and 0.474 person-years; and 10.61, 11.48 person-years per 100 thousand persons and 27.75 person-years per 100 thousand persons with the common GBD method, modified GBD method and the quality of life method, respectively. The YLDs of the patients with advanced schistosomiasis japonica in Hunan Province estimated with the modified GBD method and the quality of life method were 8.14% and 2.61 times higher than that with the common GBD method. Of the major symptoms included in the calculation, the 5 symptoms with the greatest contribution to the burden of advanced schistosomiasis japonica included ascites, moderate anemia, severe anemia, diarrhea and hematochezia.

CONCLUSIONS

The quality of life method may more comprehensively assess the YLDs in patients with advanced schistosomiasis japonica than the common and modified GBD methods.

摘要

目的

比较晚期日本血吸虫病伤残调整生命年(DALYs)的评估方法,为准确评估晚期日本血吸虫病负担提供科学依据。

方法

纳入2017年在湖南省接受治疗及救助项目的晚期日本血吸虫病患者,采用常用的全球疾病负担(GBD)估计方法、增加晚期日本血吸虫病常见综合征的改良GBD方法及生活质量评估方法计算晚期日本血吸虫病患者的伤残损失生命年(YLD)。

结果

采用常用GBD方法、改良GBD方法及生活质量方法计算的晚期日本血吸虫病患者的YLD分别为673.94、728.77人年和1761.99人年;人均YLD分别为0.181、0.196人年和0.474人年;每10万人的YLD分别为10.61、11.48人年和27.75人年。采用改良GBD方法和生活质量方法估算的湖南省晚期日本血吸虫病患者的YLD分别比常用GBD方法高8.14%和2.61倍。在计算所纳入的主要症状中,对晚期日本血吸虫病负担贡献最大的5种症状为腹水、中度贫血、重度贫血、腹泻和便血。

结论

与常用GBD方法和改良GBD方法相比,生活质量方法可能更全面地评估晚期日本血吸虫病患者的YLD。

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