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以反应性低血糖症状入院的胰岛素瘤病例

Insulinoma Case Admitted with Reactive Hypoglycemia Symptoms.

作者信息

Koca Nizameddin, Cander Soner, Gul Ozen Oz, Uğraş Nesrin

机构信息

Department of Internal Medicine, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkey.

Department of Internal Medicine, Division of Endocrinology & Metabolism, Uludağ University Medical School, Bursa, Turkey.

出版信息

Curr Diabetes Rev. 2020;16(7):790-796. doi: 10.2174/1573399815666190712200716.

Abstract

AIM

To present an insulinoma case with post-prandial hypoglycemic symptoms associated with glucose inducible endogenous hyperinsulinemia.

CASE

A 52-year-old female patient was evaluated for hypoglycemic symptoms especially those occuring within 3 hours after consuming sugary foods. These symptoms were persistent for a year and a half. She was diagnosed with reactive (post-prandial) syndrome and followed a recommended diet and was given acarbose but there was no improvement. The results suggested post-prandial endogenous hyperinsulinemia related hypoglycemia. Multiphasic computerized tomography revealed an 11x15x12 mm size mass lesion, anteriorly in the head and uncinate process of the pancreas and then the patients were treated surgically with pancreatic enucleation and cured.

CONCLUSION

Distinguishing post-prandial syndrome by careful history and clinical evaluation in patients with postprandial symptoms is of great importance in terms of cost-effectivity. However, it should not be forgotten that although organic pathologies are mostly presented with fasting hypoglycemia, they may also cause post-prandial symptoms. Severity and progression of the symptoms that point to neuroglycopenia is important, and in this condition the most convenient clinical approach to the patient should be performed with careful and appropriate assessment steps.

摘要

目的

报告一例胰岛素瘤病例,该病例具有与葡萄糖诱导的内源性高胰岛素血症相关的餐后低血糖症状。

病例

一名52岁女性患者因低血糖症状接受评估,尤其是食用含糖食物后3小时内出现的症状。这些症状持续了一年半。她被诊断为反应性(餐后)综合征,遵循推荐饮食并服用阿卡波糖,但症状无改善。结果提示餐后内源性高胰岛素血症相关性低血糖。多期计算机断层扫描显示胰腺头部和钩突前部有一个大小为11×15×12毫米的肿块病变,随后患者接受了胰腺肿瘤剜除术并治愈。

结论

对于有餐后症状的患者,通过仔细询问病史和临床评估来鉴别餐后综合征在成本效益方面非常重要。然而,不应忘记,尽管器质性病变大多表现为空腹低血糖,但也可能导致餐后症状。指向脑低血糖症的症状的严重程度和进展很重要,在这种情况下,应对患者采取最便捷的临床方法,并进行仔细且恰当的评估步骤。

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