Podgórska Marta, Diakowska Dorota, Pietraszek-Gremplewicz Katarzyna, Nienartowicz Miroslaw, Nowak Dorota
Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
Department of Nervous System Diseases, Wroclaw Medical University, 51-618 Wroclaw, Poland.
J Clin Med. 2019 Sep 20;8(10):1513. doi: 10.3390/jcm8101513.
Colorectal cancer is the second deadliest tumor, which has a positive correlation with obesity which led to increasing interest in the relationship between adipokines and cancer progression. Apelin is a secreted peptide involved in regulation of tumor progression and invasiveness. In this study, we examined apelin and apelin receptor expression level in colorectal cancer. Apelin, and its receptor mRNA, and protein expression levels were measured in tumor tissue of 56 surgically treated colorectal adenocarcinoma (CRC) patients. We also analyzed apelin and apelin receptor protein levels in sera of 56 CRC patients and 27 healthy controls. The mRNA and protein level of this peptide and its receptor was higher in tumors than that in control tissue. Serum levels of apelin and apelin receptor were increased in CRC patients in comparison to controls. The concentration of serum apelin level significantly increased in individuals with lymph node and distant metastasis. Obtained results suggest that apelin could be an important factor in progression of colorectal carcinoma.
结直肠癌是第二大致命性肿瘤，它与肥胖呈正相关，这引发了人们对脂肪因子与癌症进展之间关系的日益关注。Apelin是一种分泌型肽，参与肿瘤进展和侵袭的调节。在本研究中，我们检测了结直肠癌中Apelin及其受体的表达水平。对56例接受手术治疗的结直肠腺癌（CRC）患者的肿瘤组织进行了Apelin及其受体mRNA和蛋白表达水平的检测。我们还分析了56例CRC患者和27例健康对照者血清中的Apelin及其受体蛋白水平。该肽及其受体的mRNA和蛋白水平在肿瘤中高于对照组织。与对照组相比，CRC患者血清中Apelin及其受体水平升高。有淋巴结转移和远处转移的个体血清Apelin水平浓度显著升高。所得结果表明，Apelin可能是结直肠癌进展的一个重要因素。
