Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden.
Department of Physics, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden.
Nat Commun. 2019 Sep 27;10(1):4426. doi: 10.1038/s41467-019-12458-1.
Studying single catalyst nanoparticles, during reaction, eliminates averaging effects that are an inherent limitation of ensemble experiments. It enables establishing structure-function correlations beyond averaged properties by including particle-specific descriptors such as defects, chemical heterogeneity and microstructure. Driven by these prospects, several single particle catalysis concepts have been implemented. However, they all have limitations such as low throughput, or that they require very low reactant concentrations and/or reaction rates. In response, we present a nanofluidic device for highly parallelized single nanoparticle catalysis in solution, based on fluorescence microscopy. Our device enables parallel scrutiny of tens of single nanoparticles, each isolated inside its own nanofluidic channel, and at tunable reaction conditions, ranging from the fully mass transport limited regime to the surface reaction limited regime. In a wider perspective, our concept provides a versatile platform for highly parallelized single particle catalysis in solution and constitutes a promising application area for nanofluidics.
在反应过程中研究单个催化剂纳米粒子，可以消除整体实验固有的平均效应限制。它通过包含颗粒特定描述符（如缺陷、化学异质性和微观结构），使我们能够建立超越平均性质的结构-功能相关性。受这些前景的推动，已经实施了几种单颗粒催化概念。然而，它们都存在一些局限性，例如低吞吐量，或者它们需要非常低的反应物浓度和/或反应速率。针对这些问题，我们提出了一种基于荧光显微镜的用于溶液中单纳米颗粒催化的高度并行化纳米流控装置。我们的装置能够平行地检查数十个单个纳米颗粒，每个纳米颗粒都隔离在自己的纳米流道内，并可在可调的反应条件下进行研究，范围从完全受质量传输限制的区域到表面反应限制的区域。从更广泛的角度来看，我们的概念为溶液中单颗粒催化的高度并行化提供了一个通用平台，是纳米流控的一个有前途的应用领域。
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