12/15-脂氧合酶对缺血性脑卒中后脑出血的作用。
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
机构信息
Neuroprotection Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital of Jinan University, Zhuhai, Guangdong, China.
出版信息
Adv Exp Med Biol. 2019;1161:125-131. doi: 10.1007/978-3-030-21735-8_12.
Abstract
Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke.
摘要
缺血性中风是由一个或多个血栓引起的，这些血栓通常阻塞大脑中的一条主要动脉，但也经常导致血脑屏障渗漏和随后的出血。虽然长期以来人们一直知道，酶 12/15-脂氧合酶（12/15-LOX）在缺血性中风后上调，并有助于神经元细胞死亡，但最近的研究表明，12/15-LOX 在导致这种出血性转化中还有一个重要作用。这些发现对使用 12/15-LOX 抑制剂治疗中风具有重要意义。
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