Souri E, Rahmatpoor S, Barazandeh Tehrani M
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
Ann Pharm Fr. 2019 Nov;77(6):460-467. doi: 10.1016/j.pharma.2019.08.002. Epub 2019 Sep 26.
Bupropion is a noradrenaline and dopamine reuptake inhibitor which is used as an antidepressant drug. Few HPLC and spectrophotometric methods have been reported before for the determination of bupropion. Most of the previous methods reported for determination of bupropion in pharmaceutical dosage forms are somehow dangerous to health and environment because of using organic solvents.
In the present method bupropion was determined in pharmaceutical dosage forms by spectrofluorimetry after ion-pair complex formation with eosin Y. The ion-pair complex formation was optimized for reagent amount, buffer pH and time.
The developed method was linear over the range of 3-120μgmL with an acceptable precision (CV<1.5%) and accuracy (Error<1%).
The present method is applicable for determination of bupropion in pharmaceutical dosage forms for routine quality control analysis.
安非他酮是一种去甲肾上腺素和多巴胺再摄取抑制剂，用作抗抑郁药。此前很少有高效液相色谱法和分光光度法用于测定安非他酮。以前报道的用于测定药物剂型中安非他酮的大多数方法，由于使用有机溶剂，对健康和环境都有一定危害。
在本方法中，安非他酮与曙红Y形成离子对络合物后，通过荧光分光光度法测定药物剂型中的安非他酮。对离子对络合物的形成进行了试剂用量、缓冲液pH值和时间的优化。
所建立的方法在3 - 120μg/mL范围内呈线性，具有可接受的精密度（CV<1.5%）和准确度（误差<1%）。
本方法适用于药物剂型中安非他酮的测定，用于常规质量控制分析。
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