异维甲酸的致畸性。伴有神经病理学发现的病例报告。

Isotretinoin teratogenicity. Case report with neuropathologic findings.

作者信息

Hansen L A, Pearl G S

出版信息

Acta Neuropathol. 1985;65(3-4):335-7. doi: 10.1007/BF00687018.

Abstract

Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects. We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts. These findings are related to those reported previously.

摘要

异维甲酸是一种用于治疗痤疮的药物，已被证明具有致畸作用。我们报告了一例异维甲酸致畸的额外病例，该患者患有小脑蚓部发育不全、多处软脑膜神经胶质异位、脑积水以及皮质脊髓束异常。这些发现与先前报道的相关。