Ultradeep, targeted sequencing reveals distinct mutations in blood compared to matched bone marrow among patients with multiple myeloma.
作者信息
Coffey David G, Wu Qian V, Towlerton Andrea M H, Ornelas Sharon, Morales Alicia J, Xu Yuexin, Green Damian J, Warren Edus H
机构信息
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA.
出版信息
Blood Cancer J. 2019 Sep 30;9(10):77. doi: 10.1038/s41408-019-0238-0.
Abstract
摘要
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Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.鉴定新的突变驱动因素揭示了多发性骨髓瘤中的致癌基因依赖性。
Blood. 2018 Aug 9;132(6):587-597. doi: 10.1182/blood-2018-03-840132. Epub 2018 Jun 8.
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Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma.对多发性骨髓瘤的游离 DNA 和循环肿瘤细胞进行全外显子组测序。
Nat Commun. 2018 Apr 27;9(1):1691. doi: 10.1038/s41467-018-04001-5.
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Evolutionary biology of high-risk multiple myeloma.高危多发性骨髓瘤的进化生物学。
Nat Rev Cancer. 2017 Aug 24;17(9):543-556. doi: 10.1038/nrc.2017.63.
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The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.多发性骨髓瘤中循环肿瘤细胞的突变图谱
Cell Rep. 2017 Apr 4;19(1):218-224. doi: 10.1016/j.celrep.2017.03.025.
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Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma.循环肿瘤 DNA 分析显示空间突变异质性与骨髓瘤疾病复发一致。
Leukemia. 2017 Aug;31(8):1695-1705. doi: 10.1038/leu.2016.366. Epub 2016 Nov 30.
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Genomic complexity of multiple myeloma and its clinical implications.多发性骨髓瘤的基因组复杂性及其临床意义。
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