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Compartmentalization of local cAMP signaling in neuronal growth and survival.

作者信息

Boczek Tomasz, Kapiloff Michael S

机构信息

Department of Ophthalmology, Byers Eye Institute, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Molecular Neurochemistry, Medical University of Lodz, Poland.

Department of Ophthalmology, Byers Eye Institute, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA, USA.

出版信息

Neural Regen Res. 2020 Mar;15(3):453-454. doi: 10.4103/1673-5374.266055.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c17/6921356/e0526bcf323d/NRR-15-453-g001.jpg

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Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment.
J Neurosci. 2019 Jul 10;39(28):5466-5480. doi: 10.1523/JNEUROSCI.2752-18.2019. Epub 2019 May 16.
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Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.
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AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling.
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