Alterbrassinoids A-D：来源于 Fusicoccane 的具有不同碳骨架的二萜二聚体.
Alterbrassinoids A-D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons from .
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , P. R. China.
College of Pharmacy , Hubei University of Medicine , Shiyan 442000 , P. R. China.
出版信息
Org Lett. 2019 Oct 18;21(20):8353-8357. doi: 10.1021/acs.orglett.9b03133. Epub 2019 Oct 1.
Alterbrassinoids A-D (-), the first examples of fusicoccane-derived diterpenoid dimers furnished by forming an undescribed C-12-C-18' linkage, were isolated from modified cultures of . Compounds and represent unprecedented heterodimers, whereas and represent unprecedented homodimers, and also features an undescribed anhydride motif. Their structures were assigned via spectroscopic methods, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Putative biosynthetic pathways and a bioactivity evaluation for - were discussed.
从 经修饰的培养物中分离得到了 Alterbrassinoids A-D(-)，这是首次发现的由未描述的 C-12-C-18' 键连接形成的 fusicoccane 衍生二萜二聚体。化合物 和 代表了前所未有的杂二聚体，而 和 代表了前所未有的同二聚体，并且 还具有未描述的酸酐基序。通过光谱方法、电子圆二色性计算和单晶 X 射线衍射确定了它们的结构。讨论了 - 的假定生物合成途径和生物活性评价。
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