口服补液溶液可使溃疡性结肠炎患者在直肠结肠切除术后的血浆肾素和醛固酮水平恢复正常。

Oral rehydration solution normalizes plasma renin and aldosterone levels in patients with ulcerative colitis after proctocolectomy.

作者信息

Kudoh Katsuyoshi, Shibata Chikashi, Funayama Yuji, Fukushima Kouhei, Takahashi Kenichi, Nagao Munenori, Haneda Sho, Watanabe Kazuhiro, Naitoh Takeshi, Unno Michiaki

机构信息

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Tohoku Medical and Parmaceutical University, Sendai, Japan.

出版信息

J Anus Rectum Colon. 2018 May 25;1(3):78-83. doi: 10.23922/jarc.2016-015. eCollection 2017.

DOI:10.23922/jarc.2016-015

PMID:31583305

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6768676/

Abstract

OBJECTIVES

The possible effects and benefits of oral rehydration solution (ORS) on chronic dehydration after total proctocolectomy.

METHODS

To evaluate the effect of ORS on the renin-angiotensin system after remnant proctocolectomy in patients with ulcerative colitis (UC), we selected 20 patients after remnant proctocolectomy, ileal J pouch-anal anastomosis, and construction of a diverting ileostomy for UC. Patients were randomly divided into two groups, A (n=9) or B (n=11), 2 weeks after the surgery. In group A, ORS (1000 mL/day) was given for the first 7 days and mineral water (1000 mL/day) for the next 7 days. In group B, mineral water (1000 mL/day) was given for the first 7 days and ORS (1000 mL/day) for next 7 days. Plasma levels of renin, aldosterone and excretion of sodium in urine were evaluated at days 0, 7, and 14. We defined day 0 as the day of beginning this study.

RESULTS

Mean plasma renin levels on day 0 were six to eight times greater than the upper normal limit. In group A, ORS lowered plasma renin levels. In group B, plasma levels of renin and aldosterone after ORS were lower than those at days 0 and 7.

CONCLUSIONS

ORS corrected increased plasma levels of renin and aldosterone to within the normal range in patients after proctocolectomy.

摘要

目的

口服补液盐（ORS）对全直肠结肠切除术后慢性脱水的可能影响及益处。

方法

为评估ORS对溃疡性结肠炎（UC）患者残余直肠结肠切除术后肾素 - 血管紧张素系统的影响，我们选取了20例接受残余直肠结肠切除术、回肠J袋肛管吻合术并为UC构建转流性回肠造口术的患者。术后2周，患者被随机分为两组，A组（n = 9）和B组（n = 11）。A组在前7天给予ORS（1000 mL/天），后7天给予矿泉水（1000 mL/天）。B组在前7天给予矿泉水（1000 mL/天），后7天给予ORS（1000 mL/天）。在第0天、第7天和第14天评估血浆肾素、醛固酮水平以及尿钠排泄。我们将第0天定义为本研究开始之日。