富含芹菜素的（德吉拉德）孔茨促进HCT116癌细胞的凋亡。
Apigenin rich- (de Girard) Kuntze promotes apoptosis in HCT116 cancer cells.
作者信息
Hamadou Meriem Hadjer, Kerkatou Messaoud, Gatto Pamela, Pancher Michael, Bisio Alessandra, Inga Alberto, Menad Ahmed, Benayache Samir, Benayache Fadila, Ameddah Souad
机构信息
Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université Frères Mentouri Constantine 1, Constantine, Algérie.
Unité de Recherche: Valorisation des Ressources Naturelles, Molecules ́ Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université́ Frères ̀ Mentouri, Constantine, Algérie.
出版信息
Nat Prod Res. 2021 Sep;35(17):2910-2914. doi: 10.1080/14786419.2019.1672070. Epub 2019 Oct 9.
The pro-apoptotic property of -BuOH extract of (BEL) and its major isolated components [apigenin (APG1) and apigenin7-O-β-D-(6''-methylglucuronide) (APG2)] were tested. The anti-proliferative IC of BEL and APG1 was quantified as 7.60 µg/mL and 25.74 µM respectively, while APG2 did not affect cell proliferation in HCT116 p53 wild type cells. Growth inhibition by BEL treatment was associated with reduced signaling from the MAP kinase, activation of the p53 response pathway and PARP cleavage. The multi-effect of could be due through their major apigenin compounds and the other bioactive constituents that may possibly act in synergy to exercise the most favorable anti-tumor activities.
对白花蛇舌草（BEL）的正丁醇提取物及其主要分离成分[芹菜素（APG1）和芹菜素7 - O - β - D -（6'' - 甲基葡萄糖醛酸苷）（APG2）]的促凋亡特性进行了测试。BEL和APG1的抗增殖IC50分别定量为7.60μg/mL和25.74μM，而APG2在HCT116 p53野生型细胞中不影响细胞增殖。BEL处理引起的生长抑制与丝裂原活化蛋白激酶信号传导减少、p53反应途径激活和聚（ADP - 核糖）聚合酶（PARP）裂解有关。白花蛇舌草的多重效应可能归因于其主要的芹菜素化合物以及其他可能协同作用以发挥最有利抗肿瘤活性的生物活性成分。
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