Li Fei, Zhang Dong-Bo, Li Jing-Tao, He Feng-Jie, Zhu Hong-Li, Li Nan, Xiao Xin-Chun, Ren Li, Zheng Wei
Shaanxi University of Chinese Medicine, Xianyang, P.R. China.
Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xianyang, P.R. China.
Nat Prod Res. 2021 Sep;35(17):2849-2857. doi: 10.1080/14786419.2019.1675062. Epub 2019 Oct 9.
Two new highly-oxygenated -clerodane diterpenoids, 3-acetoxyl-mollotucin D dilactone ester () and 6-crotoeurin C (), and a new lupane-type triterpene, 16β-hydroxyl-3β---coumaroyl-betulin (), as well as three known analogues () were obtained from the leaves of . The structures of the new compounds were determined by extensive spectroscopic methods, and their absolute configurations were determined by combination of single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) spectra, and literature data. Compounds and exhibited inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC values of 1.2 and 1.6 μM, respectively. Additionally, compound exhibited activity against Col205 and HepG2 cell lines with IC values of 12.9 and 17.7 μM, respectively.
从[植物名称]的叶子中获得了两种新的高度氧化的克罗烷二萜类化合物，3-乙酰氧基-莫洛图辛D双内酯酯（）和6-巴豆欧瑞因C（），以及一种新的羽扇豆烷型三萜，16β-羟基-3β---香豆酰桦木醇（），还有三种已知类似物（）。通过广泛的光谱方法确定了新化合物的结构，并通过单晶X射线衍射分析、电子圆二色性（ECD）光谱和文献数据相结合的方式确定了它们的绝对构型。化合物和在RAW 264.7巨噬细胞中对脂多糖（LPS）诱导的一氧化氮（NO）产生具有抑制活性，IC值分别为1.2和1.6μM。此外，化合物对Col205和HepG2细胞系具有活性，IC值分别为12.9和17.7μM。
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