Department of Trauma and Orthopaedic Surgery, AOU San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, 84131 Salerno, Italy.
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, SA, Italy.
Br Med Bull. 2019 Dec 11;132(1):33-44. doi: 10.1093/bmb/ldz028.
Osteoarthritis (OA) is a most common orthopaedic condition, often complicated by inflammatory features.
A systematic search in PubMed, Embase, Google Scholar and Scopus databases (to January 2019) was performed to define the effect obtained in patients with OA of the knee by injections of ozone, on pain and physical function. Six RCTs and 353 patients were included.
Recently, an increasing number of physicians have used ozone therapy to alleviate the symptoms of acute and chronic OA of the knee. Ozone can allow greater mobility of the knee joint, pain relief and decrease in effusion.
The volume and concentration of ozone injected are different in the various treatment protocols published.
The action of ozone is unclear, but it is a promising therapeutic modality capable of impacting, favourably, function and quality of life.
The lack of a clear protocol of use is a major limitation, and to date there is no clear evidence of long-term efficacy.
骨关节炎（OA）是最常见的骨科疾病，常伴有炎症特征。
对 PubMed、Embase、Google Scholar 和 Scopus 数据库（截至 2019 年 1 月）进行了系统检索，以确定膝关节 OA 患者接受臭氧注射治疗后在疼痛和身体功能方面的疗效。共纳入 6 项 RCT 和 353 名患者。
最近，越来越多的医生使用臭氧疗法来缓解急性和慢性膝关节 OA 的症状。臭氧可以增加膝关节的活动度，缓解疼痛并减少积液。
在已发表的各种治疗方案中，注射的臭氧量和浓度有所不同。
臭氧的作用机制尚不清楚，但它是一种很有前途的治疗方法，能够对功能和生活质量产生有利影响。
使用缺乏明确的方案是一个主要限制，迄今为止，臭氧治疗的长期疗效尚无明确证据。
Zotero 插件