微小RNA-34a抑制膀胱癌细胞的迁移和侵袭，并上调PTEN的表达。
MicroRNA-34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression.
作者信息
Ding Zhen-Shan, He Yu-Hui, Deng Yi-Sen, Peng Pan-Xin, Wang Jian-Feng, Chen Xing, Zhao Pei-Yu, Zhou Xiao-Feng
机构信息
Department of Urology, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
Department of Urology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, P.R. China.
出版信息
Oncol Lett. 2019 Nov;18(5):5549-5554. doi: 10.3892/ol.2019.10877. Epub 2019 Sep 18.
MicroRNA-34a (miR-34a) serves as a tumor suppressor in a number of different types of cancer. The present study was performed to investigate the involvement of miR-34a in bladder cancer. In the present study, miR-34a was downregulated in patients with bladder cancer compared with the healthy controls in bladder biopsies and plasma. Downregulation of miR-34a distinguished between patients with bladder cancer and the healthy controls. miR-34a expression was associated with tumor metastasis; however, not with tumor size. Transfection of miR-34a mimics upregulated the expression of phosphatase and tensin homolog (PTEN) in bladder cancer cells, and decreased cell migration and invasion. miR-34a may inhibit bladder cancer cell migration and invasion by upregulating PTEN. miR-34a may additionally serve as a potential therapeutic target for bladder cancer.
微小RNA-34a（miR-34a）在多种不同类型的癌症中发挥肿瘤抑制作用。本研究旨在探讨miR-34a在膀胱癌中的作用。在本研究中，与膀胱活检组织和血浆中的健康对照相比，膀胱癌患者的miR-34a表达下调。miR-34a的下调可区分膀胱癌患者和健康对照。miR-34a表达与肿瘤转移相关，但与肿瘤大小无关。转染miR-34a模拟物可上调膀胱癌细胞中磷酸酶和张力蛋白同源物（PTEN）的表达，并减少细胞迁移和侵袭。miR-34a可能通过上调PTEN来抑制膀胱癌细胞的迁移和侵袭。miR-34a还可能作为膀胱癌的潜在治疗靶点。
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