烟酸对 HCAR2 的激活：降脂之外的益处。
Activation of HCAR2 by niacin: benefits beyond lipid lowering.
机构信息
Department of Medicine, Division of Translational Medicine & Human Genetics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 11-143, Philadelphia, PA 19104, USA.
出版信息
Pharmacogenomics. 2019 Nov;20(16):1143-1150. doi: 10.2217/pgs-2019-0092. Epub 2019 Oct 16.
Niacin (nicotinic acid) is a potent lipid-lowering agent that has been used for prevention of coronary heart disease. Niacin activates the HCAR2 receptor found on adipocytes, macrophages and various immune cells throughout the body. Activation of the HCAR2 receptor by niacin results in beneficial anti-inflammatory effects that are independent of lipid lowering. This review summarizes the use of niacin in treatment of dyslipidemia, the pharmacogenetics of niacin response and the potential role of HCAR2 signaling in the treatment of a variety of inflammatory and metabolic diseases.
烟酸（烟碱酸）是一种强效的降脂药物，已被用于预防冠心病。烟酸激活全身脂肪细胞、巨噬细胞和各种免疫细胞上的 HCAR2 受体。烟酸激活 HCAR2 受体可产生有益的抗炎作用，而与降低血脂无关。本综述总结了烟酸在治疗血脂异常中的应用、烟酸反应的药物遗传学以及 HCAR2 信号在治疗各种炎症和代谢性疾病中的潜在作用。
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