A t (11;21) (13;q22) in Ph-positive chronic myelogenous leukemia.
作者信息
Wang T Y, Raza A, Sait S N, Stein A, Schumer J, Sandberg A A
机构信息
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
出版信息
Cancer Genet Cytogenet. 1988 Apr;31(2):187-91. doi: 10.1016/0165-4608(88)90216-6.
PMID:3162392
Abstract
Reciprocal translocations, in addition to that of the Ph chromosome, though rare, have been reported in chronic myelogenous leukemia (CML). We describe here a case of Ph-positive CML with a new translocation, t (11;21) (q13;q22), and missing Y, which were present both during transformation to the blastic crisis and in the subsequent reversion to the chronic phase. The possible significance of this abnormality is discussed.
摘要
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