获得性免疫缺陷综合征患者中伯基特淋巴瘤-白血病的细胞遗传学研究。

Cytogenetic studies of Burkitt lymphoma-leukemia in patients with acquired immunodeficiency syndrome.

作者信息

Bernheim A, Berger R

机构信息

Laboratoire de Cytogénétique, Unité INSERM U301, Hôpital St. Louis, Paris, France.

出版信息

Cancer Genet Cytogenet. 1988 May;32(1):67-74. doi: 10.1016/0165-4608(88)90313-5.

DOI:10.1016/0165-4608(88)90313-5

PMID:3162708

Abstract

The frequency of Burkitt lymphoma-leukemia (BL) is high in patients with acquired immunodeficiency syndrome (AIDS). We describe four such cases, three with a translocation t(8;14)(q24;q32) and one with a t(8;22)(q24;q11). No Epstein-Barr virus genome was found in the tumorous cells of this patient. Including these cases, 13 patients with AIDS-associated BL have been reported so far with specific translocations. Three had a t(8q+; 22q-) variant translocation and the other ten patients had the t(8q-; 14q+). Associated chromosomal abnormalities were as frequent as in ordinary BL and were comparable with those occurring in cases of other BL, such as partial duplication of 1q and 13q34 rearrangements. Trisomy 12, however, was observed in 3 out of 13 AIDS-associated BL cases.

摘要

在获得性免疫缺陷综合征（AIDS）患者中，伯基特淋巴瘤白血病（BL）的发病率很高。我们描述了4例此类病例，其中3例有t(8;14)(q24;q32)易位，1例有t(8;22)(q24;q11)易位。在该患者的肿瘤细胞中未发现爱泼斯坦-巴尔病毒基因组。包括这些病例在内，迄今为止已报道了13例伴有特定易位的艾滋病相关BL患者。3例有t(8q+; 22q-)变异易位，其他10例患者有t(8q-; 14q+)易位。相关染色体异常与普通BL一样常见，并且与其他类型BL病例中出现的异常相当，如1q部分重复和13q34重排。然而，在13例艾滋病相关BL病例中有3例观察到12号染色体三体。