Ucpinar Burak, Erbin Akif, Ayranci Ali, Caglar Ufuk, Alis Deniz, Basal Seref, Sarilar Omer, Akbulut Mehmet Fatih
Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.
J BUON. 2019 Jul-Aug;24(4):1659-1665.
To evaluate patients, diagnosed with non-muscle invasive bladder cancer, according to patient specific parameters including hemoglobin level, estimated glomerular filtration rate (eGFR), body mass index (BMI) and cigarette smoking and to identify if any of these parameters matters in terms of recurrence prediction.
231 patients who have undergone transurethral resection of the bladder (TURB) between January 2015 and January 2018 and diagnosed with non-muscle invasive bladder cancer (NMIBC) were included. Patient demographic characteristics including age, sex, BMI and cigarette smoking were assessed. Hemoglobin, creatinine and eGFR values were recorded. Follow-up was performed according to the European Association of Urology (EAU) guidelines' recommendations. Recurrence and progression during follow-up were recorded.
231 patients were included in the study. Median patient BMI, Hb levels, and eGFR values were 26.51 kg/m2 (IQR 5.48), 14,2 g/dL (IQR 2.50), and 83.25 ml/min/1.73m2 (IQR 27.83), respectively. Among all patients, 105 (45%) were ex-smokers and 78 (33%) were current smokers, 41 had anemia (17.7%), 37 (16%) patients were obese; 104 (45%) had mildly impaired renal function and 34 (14.7%) had impaired renal function. During follow-up, 67 (29%) patients had disease recurrence and 21 (9.1%) had disease progression (9.1%). Univariate and multivariate analyses revealed significant relationship between recurrence and obesity, impaired renal function and cigarette smoking.
Recurrence is a commonly encountered unfortunate consequence of NMIBC, and obesity, renal failure, history of smoking and anemia seem to increase the rate of recurrence among bladder cancer patients.
根据患者特定参数（包括血红蛋白水平、估计肾小球滤过率（eGFR）、体重指数（BMI）和吸烟情况）对诊断为非肌肉浸润性膀胱癌的患者进行评估，并确定这些参数中的任何一个在复发预测方面是否具有重要意义。
纳入2015年1月至2018年1月间接受经尿道膀胱肿瘤切除术（TURB）并诊断为非肌肉浸润性膀胱癌（NMIBC）的231例患者。评估患者的人口统计学特征，包括年龄、性别、BMI和吸烟情况。记录血红蛋白、肌酐和eGFR值。根据欧洲泌尿外科学会（EAU）指南的建议进行随访。记录随访期间的复发和进展情况。
231例患者纳入研究。患者的BMI中位数、血红蛋白水平和eGFR值分别为26.51kg/m²（四分位间距5.48）、14.2g/dL（四分位间距2.50）和83.25ml/min/1.73m²（四分位间距27.83）。在所有患者中，105例（45%）为既往吸烟者，78例（33%）为当前吸烟者，41例有贫血（17.7%），37例（16%）患者肥胖；104例（45%）肾功能轻度受损，34例（14.7%）肾功能受损。随访期间，67例（29%）患者疾病复发，21例（9.1%）患者疾病进展（9.1%）。单因素和多因素分析显示复发与肥胖、肾功能受损和吸烟之间存在显著关系。
复发是非肌肉浸润性膀胱癌常见的不良后果，肥胖、肾衰竭、吸烟史和贫血似乎会增加膀胱癌患者的复发率。
