基于动态胎儿-胎盘比例定律的胎儿生长曲线。
Gestational growth trajectories derived from a dynamic fetal-placental scaling law.
机构信息
Department of Mathematical Sciences, United States Military Academy, West Point, NY 10996, USA.
Department of Computer Science, Montclair State University, Montclair, NJ 07043, USA.
出版信息
J R Soc Interface. 2019 Oct 31;16(159):20190417. doi: 10.1098/rsif.2019.0417. Epub 2019 Oct 30.
Abstract
Fetal trajectories characterizing growth rates have relied primarily on goodness of fit rather than mechanistic properties exhibited . Here, we use a validated fetal-placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal-placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events .
摘要
用于描述生长速度的胎儿轨迹主要依赖于拟合优度，而不是表现出的机械特性。在这里，我们使用经过验证的胎儿-胎盘比例缩放定律和胎盘体积生长的第一原理微分方程模型来生成具有生物学意义的胎儿-胎盘生长曲线。这些生长曲线为理解健康与高危胎儿生长以及识别关键事件的时间提供了基础。
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