白细胞介素和 microRNAs 干预 2 型糖尿病患者糖尿病肾病的早期阶段。
Interleukins and miRNAs intervene in the early stages of diabetic kidney disease in Type 2 diabetes mellitus patients.
机构信息
Department of Nephrology, 'Victor Babes' University of Medicine & Pharmacy, Romania.
Centre of Translational Research & Systems Medicine, 'Victor Babes' University of Medicine & Pharmacy, 300041 Timisoara, Romania.
出版信息
Biomark Med. 2019 Dec;13(18):1577-1588. doi: 10.2217/bmm-2019-0124. Epub 2019 Oct 30.
The involvement of proinflammatory interleukins (IL) in diabetic kidney disease of Type 2 diabetes mellitus (DM) patients was studied in relation to a particular miRNA profile. A total of 117 patients with Type 2 DM and 11 controls were enrolled in a case series study. Serum and urinary ILs and miRNAs were assessed. IL-1α correlated with miRNA21, 124, estimated glomerular filtration rate (eGFR) and negatively with miRNA125a and 192; IL-8 with miRNA21, 124, eGFR and negatively with miRNA125a, 126 and 146a; IL-18 with miRNA21, 124 and negatively with miRNA146a, 192, eGFR. There is an association between specific serum and urinary ILs and serum and urinary miRNAs profiles in the inflammatory response in Type 2 DM patients with diabetic kidney disease.
研究了与特定 miRNA 谱相关的 2 型糖尿病（DM）患者糖尿病肾病中促炎白细胞介素（IL）的作用。一项病例系列研究纳入了 117 例 2 型 DM 患者和 11 例对照。评估了血清和尿液中的 IL 和 miRNA。IL-1α 与 miRNA21、124、估算肾小球滤过率（eGFR）呈正相关，与 miRNA125a 和 192 呈负相关；IL-8 与 miRNA21、124、eGFR 呈正相关，与 miRNA125a、126 和 146a 呈负相关；IL-18 与 miRNA21、124 呈正相关，与 miRNA146a、192、eGFR 呈负相关。在 2 型 DM 合并糖尿病肾病患者的炎症反应中，特定的血清和尿液 ILs 与血清和尿液 miRNA 谱之间存在关联。
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