人表皮样肺癌异种移植瘤系中耐药性的产生
Development of drug resistance in a human epidermoid lung carcinoma xenograft line.
作者信息
Mattern J, Bak M, Hoever K H, Volm M
机构信息
Institute of Experimental Pathology, German Cancer Research Center, Heidelberg.
出版信息
Br J Cancer. 1988 Jul;58(1):30-3. doi: 10.1038/bjc.1988.155.
The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour responsiveness to these drugs. A partial resistance was already acquired at the 2nd transplant generation. In contrast, a gradual decrease in therapeutic response was observed with 10 mg kg-1 cisplatin. Irradiation with a local dose of 10 Gy induced no resistance. The three induced drug-resistant sublines were characterized in terms of the time course of development of resistance, the degree of induced resistance, cross-resistance, growth rate and stability of the phenotype.
在裸鼠体内生长的人肺表皮样癌异种移植系（HXL 55）中，已对长春新碱、放线菌素D和顺铂的耐药性发展进行了研究。在每次体内传代时，用1 mg kg-1长春新碱或0.5 mg kg-1放线菌素D处理HXL 55，导致肿瘤对这些药物的反应迅速降低。在第2代移植时就已获得部分耐药性。相比之下，用10 mg kg-1顺铂观察到治疗反应逐渐降低。局部剂量10 Gy的照射未诱导出耐药性。根据耐药性发展的时间进程、诱导耐药程度、交叉耐药性、生长速率和表型稳定性对三个诱导的耐药亚系进行了表征。
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