儿科药物基因组学检测：应对伦理、社会和法律挑战
Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges.
作者信息
Haga Susanne B
机构信息
Department of Medicine, Division of General Internal Medicine, Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, 27708, USA.
出版信息
Pharmgenomics Pers Med. 2019 Oct 14;12:273-285. doi: 10.2147/PGPM.S179172. eCollection 2019.
Abstract
For the past several years, the implementation of pharmacogenetic (PGx) testing has become widespread in several centers and clinical practice settings. PGx testing may be ordered at the point-of-care when treatment is needed or in advance of treatment for future use. The potential benefits of PGx testing are not limited to adult patients, as children are increasingly using medications more often and at earlier ages. This review provides some background on the use of PGx testing in children as well as mothers (prenatally and post-natally) and discusses the challenges, benefits, and the ethical, legal, and social implications of providing PGx testing to children.
摘要
在过去几年中，药物遗传学（PGx）检测在多个中心和临床实践环境中已广泛实施。当需要治疗时，PGx检测可在即时医疗点进行，也可在治疗前提前进行以备将来使用。PGx检测的潜在益处不仅限于成年患者，因为儿童越来越早且越来越频繁地使用药物。本综述提供了一些关于在儿童以及母亲（产前和产后）中使用PGx检测的背景信息，并讨论了对儿童进行PGx检测所面临的挑战、益处以及伦理、法律和社会影响。
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