Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington.
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Ann Clin Transl Neurol. 2019 Dec;6(12):2579-2585. doi: 10.1002/acn3.50934. Epub 2019 Nov 11.
We examined the effects of slow-pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI-based realistic head model was constructed for each subject and co-registered with 256-channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long-term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.
我们研究了慢脉冲经颅电刺激（TES）对 7 名耐药性癫痫成人癫痫样放电的抑制作用。为每位受试者构建了基于 MRI 的现实头部模型，并与 256 通道密集脑电图（dEEG）配准。对发作间期棘波进行定位，并针对每个受试者主要棘波群体的皮质源进行 TES 靶向。在五名受试者（总共有 29/35 天的治疗）中抑制了靶向棘波，在四名受试者中抑制了非靶向棘波。癫痫样活动没有恶化。这项研究表明，这种旨在诱导长时程抑制（LTD）的方案在急性抑制发作间期癫痫样放电方面是安全有效的。
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