Division of Cancer Biology and Inflammatory Disorder, Indian Institute of Chemical Biology, Kolkata, India.
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Kolkata, India.
Front Immunol. 2019 Oct 29;10:2551. doi: 10.3389/fimmu.2019.02551. eCollection 2019.
Wnt ligands interact with the transmembrane cell surface receptors Frizzled and ROR/RYK to initiate complex signaling cascades that are crucial for cell physiology and the proper functioning of the immune system. Wnt signaling is instrumental in maintaining immune surveillance and during infections by pathogenic microbes helps mount host resistance to infection. Some pathogens, however, utilize Wnt signaling to build a niche for their survival. The goal of this review is to summarize current and developing concepts about the tug of war between Wnt signaling and pathogens for deployment of host resources, focusing mostly on macrophages and cytoskeletal actin dynamics. An additional objective is to outline the interrelation between Wnt signaling and the host microbiota, which is vital for immune defense, discussing in the same perspective, how Wnt signaling could be differentiating pathogen from non-pathogen.
Wnt 配体与跨膜细胞表面受体 Frizzled 和 ROR/RYK 相互作用，启动复杂的信号级联反应，这对细胞生理学和免疫系统的正常功能至关重要。Wnt 信号在维持免疫监视方面发挥着重要作用，在感染病原体时，它有助于宿主抵抗感染。然而，一些病原体利用 Wnt 信号为自身的生存创造小生境。本综述的目的是总结当前和正在发展的概念，即 Wnt 信号与病原体之间为争夺宿主资源而展开的拉锯战，重点关注巨噬细胞和细胞骨架肌动蛋白动力学。另一个目标是概述 Wnt 信号与宿主微生物组之间的相互关系，这对于免疫防御至关重要，并从同一角度讨论 Wnt 信号如何区分病原体和非病原体。
