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儿科肿瘤学中的精准医学

Precision Medicine in Pediatric Oncology.

作者信息

Vo Kieuhoa T, Parsons D Williams, Seibel Nita L

机构信息

Department of Pediatrics, University of California San Francisco School of Medicine, Benioff Children's Hospital, 550 16th Street, 4th Floor, Box 0434, San Francisco, CA 94158, USA.

Section of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates Avenue, Suite 1030.15, Houston, TX 77030, USA.

出版信息

Surg Oncol Clin N Am. 2020 Jan;29(1):63-72. doi: 10.1016/j.soc.2019.08.005. Epub 2019 Oct 29.

DOI:10.1016/j.soc.2019.08.005
PMID:31757314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7819485/
Abstract

Improvements in outcome have been seen in children and adolescents with cancer. Nevertheless, challenges remain in trying to improve the outcomes for all children diagnosed with cancer, particularly in patients with metastatic disease or with cancers that are resistant or recur after standard treatment. Precision medicine trials using individualized tumor molecular profiling for selection of targeted therapies are ongoing in adult malignancies. Similar approaches are being applied to children and adolescents with cancer. This article describes how precision medicine is being applied to pediatric oncology and the unique challenges being faced with these efforts.

摘要

癌症患儿和青少年的治疗结果已有改善。然而，在努力改善所有确诊癌症儿童的治疗结果方面仍存在挑战，尤其是转移性疾病患者或标准治疗后耐药或复发癌症的患者。针对成人恶性肿瘤正在开展使用个体化肿瘤分子谱分析来选择靶向治疗的精准医学试验。类似的方法也正在应用于患癌儿童和青少年。本文描述了精准医学如何应用于儿科肿瘤学以及这些努力所面临的独特挑战。

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