Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat. - Suppr | 超能文献

Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat.

作者信息

Dahlbäck B, Hansson C, Islam M Q, Szpirer J, Szpirer C, Lundwall A, Levan G

机构信息

Department of Clinical Chemistry, University of Lund, Malmö General Hospital, Sweden.

出版信息

Somat Cell Mol Genet. 1988 Sep;14(5):509-14. doi: 10.1007/BF01534716.

DOI:10.1007/BF01534716

Abstract

Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a panel of human-rodent somatic cell hybrids. Cosegregation of factor V specific DNA restriction fragments with human chromosome 1 was observed. In addition, a panel of rat-mouse somatic cell hybrids was analyzed with another human factor V cDNA probe to localize the gene for rat coagulation factor V. In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13.

摘要

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