细胞色素P450单加氧酶/可溶性环氧化物水解酶介导的类花生酸途径在结直肠癌及肥胖相关结直肠癌中的作用
Cytochrome P450 monooxygenase/soluble epoxide hydrolase-mediated eicosanoid pathway in colorectal cancer and obesity-associated colorectal cancer.
作者信息
Zhang Jianan, Sanidad Katherine Z, Zhang Guodong
机构信息
Department of Food Science, University of Massachusetts, Amherst, MA, USA.
Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, USA.
出版信息
Oncoscience. 2019 Aug 23;6(9-10):371-375. doi: 10.18632/oncoscience.488. eCollection 2019 Sep.
Abstract
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths in the United States. Furthermore, it is well established that obese individuals have high risks of developing CRC, and obesity-associated CRC represents an unmet medical problem in the United States. Using a metabolomics approach, our recent research supports that the cytochrome P450 (CYP) monooxygenase/soluble epoxide hydrolase (sEH)-mediated eicosanoid pathway could play critical roles in the pathogenesis of CRC and obesity-associated CRC. Here in this review, we discuss recent studies about the roles of the CYP/sEH eicosanoid pathway in the pathogenesis of these diseases.
摘要
结直肠癌（CRC）是美国第三大常见癌症，也是癌症相关死亡的第二大主要原因。此外，众所周知，肥胖个体患CRC的风险很高，而肥胖相关的CRC是美国一个尚未解决的医学问题。通过代谢组学方法，我们最近的研究支持细胞色素P450（CYP）单加氧酶/可溶性环氧化物水解酶（sEH）介导的类花生酸途径可能在CRC和肥胖相关CRC的发病机制中起关键作用。在这篇综述中，我们讨论了关于CYP/sEH类花生酸途径在这些疾病发病机制中作用的最新研究。
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