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老年患者的帕金森综合征:流行病学、临床及治疗特征

[Parkinson's syndromes in geriatric patients : Epidemiological, clinical and therapeutic characteristics].

作者信息

Amadori K, Steiner T

机构信息

Klinik für Altersmedizin, Klinikum Frankfurt Höchst, Gotenstraße 6-8, 65929, Frankfurt am Main, Deutschland.

Klinik für Neurologie, Klinikum Frankfurt Höchst, Frankfurt am Main, Deutschland.

出版信息

Nervenarzt. 2019 Dec;90(12):1279-1291. doi: 10.1007/s00115-019-00825-8.

Abstract

Due to their high prevalence, Parkinson's syndromes are exemplary geriatric syndromes. In addition to idiopathic Parkinson's disease, drug-induced and vascular Parkinson's syndromes are especially relevant in older age. A comprehensive anamnesis, thorough clinical neurological examination and rational additional diagnostics ensure the correct differential diagnostic classification. The multidimensional geriatric assessment is used to quantify the syndrome-specific ability impairments. The primary therapeutic objective in old age is the preservation of everyday competences. Drug treatment is centered around L‑dopa because of its favorable effect-side effect ratio. In cases of motor fluctuations, entacapone, opicapone or safinamide can be added, whereas dopamine agonists are generally unsuitable. Rivastigmine is indicated in mild to moderate Parkinson's dementia and furthermore can possibly improve gait stability. Speech therapy, as well as physical and occupational therapy, including the Parkinson's disease-specific Lee Silverman voice treatment are indispensable components of the multiprofessional treatment concept.

摘要

由于帕金森综合征的高患病率,它们是典型的老年综合征。除特发性帕金森病外,药物性和血管性帕金森综合征在老年人群中尤为常见。全面的病史采集、 thorough临床神经学检查和合理的附加诊断可确保正确的鉴别诊断分类。多维老年评估用于量化综合征特异性的能力损害。老年患者的主要治疗目标是维持日常能力。由于左旋多巴具有良好的疗效-副作用比,药物治疗以其为核心。在出现运动波动的情况下,可加用恩他卡朋、奥匹卡朋或沙芬酰胺,而多巴胺激动剂通常不适用。利斯的明适用于轻度至中度帕金森病痴呆,此外还可能改善步态稳定性。言语治疗以及物理和职业治疗,包括帕金森病特异性的李氏语音治疗,是多专业治疗理念中不可或缺的组成部分。

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