Fekadu Ginenus, Chelkeba Legese, Melaku Tsegaye, Gamachu Busha, Gebre Mohammed, Bekele Firomsa, Fetensa Getahun
Department of Pharmacy, Institute of Health Science, Wollega University, Nekemte, Ethiopia.
School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia.
Ann Med Surg (Lond). 2019 Nov 15;48:135-143. doi: 10.1016/j.amsu.2019.11.003. eCollection 2019 Dec.
The number of stroke patients receiving recombinant tissue plasminogen activator (r-tPA) in developing world is extremely low. Pre-hospital delay, financial constraints and lack of infrastructure are the main barriers. Additionally, various medical, neurological and psychological complications are allied to stroke patients after the acute attack. Hence, the study was aimed to identify management protocols and encountered complications among stroke patients admitted to stroke unit of Jimma university medical center (JUMC).
Prospective observational study was conducted at stroke unit of JUMC from March 10 to July 10, 2017. All eligible consecutive stroke patients of ≥18 years were included. Data was entered to Epi data version 3.1 and analyzed using SPSS version 20.
A total of 116 eligible stroke patients were followed with mean age of 55.14 ± 14.04 years and males comprised of 62.9%. Using world health organization (WHO) criteria, 60 (51.7%) patients had ischemic while 56 (48.3%) had hemorrhagic stroke. During admission, 93 (80.2%) patients had developed at least one complication. The most complication was brain edema (increased intracranial pressure) detected in about one third of the patients (30.2%) followed by urinary incontinence (28.4%) and aspiration pneumonia (19.8%). Almost half of the patients (52.5%) had at least one past medication history. During hospitalization, 111(95.7%) of patients had received at least one medication and the median start time of the medications after hospital arrival was 15 h. The most common medication given for the patients during hospitalization were antiplatelets and statins for 63 (54.3%) patients. During discharge, about 78 (67.2%) patients had received medications and antihypertensives were the prominent medications prescribed for half of the discharged patients.
Both neurologic and medical complications were common in majority of stroke patients. But the management protocol for stroke patients was sub-optimal and lagging behind the recommended guidelines due to lack of skilled personnel, appropriate treatment and diagnostic agents. The clinical team involved in the care of stroke patients should make preparations to take preventive measures that will save a lot of lives.
在发展中国家,接受重组组织型纤溶酶原激活剂(r-tPA)治疗的中风患者数量极少。院前延误、经济限制和基础设施匮乏是主要障碍。此外,中风患者在急性发作后会出现各种医学、神经学和心理方面的并发症。因此,本研究旨在确定吉马大学医学中心(JUMC)中风单元收治的中风患者的管理方案及所遇到的并发症。
2017年3月10日至7月10日在JUMC中风单元进行了前瞻性观察研究。纳入所有年龄≥18岁的符合条件的连续中风患者。数据录入Epi data 3.1版本,并使用SPSS 20版本进行分析。
共对116例符合条件的中风患者进行了随访,平均年龄为55.14±14.04岁,男性占62.9%。根据世界卫生组织(WHO)标准,60例(51.7%)患者为缺血性中风,56例(48.3%)为出血性中风。住院期间,93例(80.2%)患者至少出现了一种并发症。最常见的并发症是脑水肿(颅内压升高),约三分之一的患者(30.2%)出现该并发症,其次是尿失禁(28.4%)和吸入性肺炎(19.8%)。几乎一半的患者(52.5%)至少有一次既往用药史。住院期间,111例(95.7%)患者至少接受了一种药物治疗,入院后用药的中位开始时间为15小时。住院期间给予患者最常见的药物是抗血小板药物和他汀类药物,63例(54.3%)患者使用了这些药物。出院时,约有78例(67.2%)患者接受了药物治疗,出院患者中有一半的主要用药是降压药。
大多数中风患者中神经学和医学并发症都很常见。但由于缺乏技术人员、适当的治疗和诊断药物,中风患者的管理方案并不理想,落后于推荐指南。参与中风患者护理的临床团队应做好准备采取预防措施,这将挽救许多生命。