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脑脊液分流术与减重手术治疗特发性颅内高压的比较

Cerebrospinal fluid diversion versus bariatric surgery in the management of idiopathic intracranial hypertension.

作者信息

Merola Joseph, Selezneva Liudmila, Perkins Ryan, Lang Jozsef, Barry Jonathan, Leach Paul

机构信息

Neurosciences Department, University Hospital of Wales, Cardiff, UK.

Morriston Hospital, Welsh Institute of Metabolic and Obesity Surgery, Abertawe Bro Morgannwg NHS Trust, Swansea, UK.

出版信息

Br J Neurosurg. 2020 Feb;34(1):9-12. doi: 10.1080/02688697.2019.1698012. Epub 2019 Dec 5.

Abstract

Idiopathic intracranial hypertension (IIH) is a condition affecting predominantly young women with increased body mass index (BMI). Obesity with the related metabolic and biochemical complications are thought to be involved in the pathogenesis of the condition. The aim of this study is to evaluate the safety, outcomes and economic implications of two treatment options for IIH. We retrospectively analysed cases of morbidly obese IIH patients treated by cerebrospinal fluid (CSF) shunting procedures between 2006 and 2016 in our department and compared their outcome with that of 69 patients undergoing bariatric surgery between 2015 and 2016. A total of 42 female patients with IIH underwent de-novo shunting procedures during the study period. There was a high rate of shunt revisions (67%) and further weight gain in the majority of patients who had the insertion of CSF shunts. Of the 69 female patients undergoing bariatric surgery 4.3% required interventions related to their surgery with a significantly fewer number of hospital inpatient days. Furthermore, in the patients undergoing bariatric surgery, there was a significant improvement in all obesity-related complications. CSF shunting procedures do not address the aetiological factor of IIH and are associated with high rates of morbidity and further weight gain. Bariatric surgery is not only efficacious in the management of patients with IIH but is associated with significant improvements in other obesity-related comorbidities. Bariatric surgery is safe and more cost-effective than CSF shunting.

摘要

特发性颅内高压(IIH)是一种主要影响体重指数(BMI)升高的年轻女性的疾病。肥胖及其相关的代谢和生化并发症被认为与该疾病的发病机制有关。本研究的目的是评估IIH两种治疗方案的安全性、疗效及经济影响。我们回顾性分析了2006年至2016年在我科接受脑脊液(CSF)分流手术治疗的病态肥胖IIH患者的病例,并将其结果与2015年至2016年接受减肥手术的69例患者的结果进行比较。在研究期间,共有42例患有IIH的女性患者接受了初次分流手术。分流修正率很高(67%),并且大多数接受CSF分流置入的患者体重进一步增加。在接受减肥手术的69例女性患者中,4.3%的患者需要进行与手术相关的干预,住院天数明显减少。此外,接受减肥手术的患者所有与肥胖相关的并发症都有显著改善。CSF分流手术不能解决IIH的病因,且发病率高并会导致体重进一步增加。减肥手术不仅对IIH患者的治疗有效,而且还能显著改善其他与肥胖相关的合并症。减肥手术安全且比CSF分流更具成本效益。

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