最多等待 10 秒，若超时请稍后重试。
David Furman, Judith Campisi, Eric Verdin, Pedro Carrera-Bastos, Sasha Targ, Claudio Franceschi, Luigi Ferrucci, Derek W Gilroy, Alessio Fasano, Gary W Miller, Andrew H Miller, Alberto Mantovani, Cornelia M Weyand, Nir Barzilai, Jorg J Goronzy, Thomas A Rando, Rita B Effros, Alejandro Lucia, Nicole Kleinstreuer, George M Slavich
Buck Institute for Research on Aging, Novato, CA, USA.
Stanford 1000 Immunomes Project, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5.
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
尽管间歇性炎症增加对于身体受伤和感染期间的生存至关重要，但最近的研究表明，某些社会、环境和生活方式因素可促进全身性慢性炎症（SCI），进而导致几种疾病，这些疾病共同构成了全球残疾和死亡的主要原因，如心血管疾病、癌症、糖尿病、慢性肾病、非酒精性脂肪肝疾病以及自身免疫性和神经退行性疾病。在本观点中，我们描述了 SCI 的多层次机制和促进这种健康损害表型的几个危险因素，包括感染、身体活动不足、不良饮食、环境和工业毒素以及心理压力。此外，我们还提出了推进 SCI 的早期诊断、预防和治疗的潜在策略。
