Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Br J Haematol. 2020 Jan;188(1):159-167. doi: 10.1111/bjh.16358. Epub 2019 Dec 6.
Immunotherapy is distinct from traditional chemotherapy in that it acts on immune cells rather than cancer cells themselves. Monoclonal antibodies targeting immune checkpoints on T cells - CTLA-4 and PD-1 - and PD-L1 on the cells of immune microenvironment are now approved for clinical use in several solid tumors and hematological malignancies. This article provides a general overview of the use of checkpoint inhibitors in hematologic malignancies with a special focus in acute myeloid leukemia.
免疫疗法与传统的化疗不同,它作用于免疫细胞而不是癌细胞本身。针对 T 细胞上的免疫检查点(CTLA-4 和 PD-1)以及免疫微环境细胞上的 PD-L1 的单克隆抗体已被批准用于几种实体瘤和血液恶性肿瘤的临床应用。本文提供了免疫检查点抑制剂在血液恶性肿瘤中的一般概述,特别关注急性髓系白血病。