一个新的研究热点：NLRP3 炎性小体激活在细胞焦亡这一关键步骤中的作用，在糖尿病及其并发症中的作用。

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications.

机构信息

Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China.

Department of Endocrinology, The Heilongjiang Provincial Hospital, Harbin 150001, China.

出版信息

Life Sci. 2020 Jan 1;240:117138. doi: 10.1016/j.lfs.2019.117138. Epub 2019 Dec 4.

DOI:10.1016/j.lfs.2019.117138

PMID:31809715

Abstract

Pyroptosis is a form of cell death mediated by gasdermin D (GSDMD); it is characterised by NLRP3 inflammasome activation, caspase activation, cell membrane pore formation, and the release of interleukin-1β and interleukin-18. NLRP3 inflammasome activation plays a central role in pyroptosis. Recent research has suggested that NLRP3 inflammasome activation may be involved in the occurrence and development of diabetes mellitus and its associated complications. This finding provided the impetus for us to clarify the significance of pyroptosis in diabetes. In this review, we summarise the current understanding of the molecular mechanisms involved in pyroptosis, as well as recent advances in the role of NLRP3 inflammasome activation and pyroptosis in the development of diabetes and diabetic complications.

摘要

细胞焦亡是一种由 gasdermin D（GSDMD）介导的细胞死亡形式；其特征在于 NLRP3 炎性体激活、半胱氨酸天冬氨酸蛋白酶激活、细胞膜孔形成以及白细胞介素-1β和白细胞介素-18 的释放。NLRP3 炎性体激活在细胞焦亡中起核心作用。最近的研究表明，NLRP3 炎性体激活可能参与糖尿病及其相关并发症的发生和发展。这一发现促使我们阐明细胞焦亡在糖尿病中的意义。在这篇综述中，我们总结了目前对细胞焦亡涉及的分子机制的理解，以及 NLRP3 炎性体激活和细胞焦亡在糖尿病及其并发症发展中的作用的最新进展。