基于多糖的系统用于靶向干细胞分化和骨再生。
Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration.
机构信息
Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359 Rheinbach, Germany.
Laboratory of Neurosciences, Department of Biochemistry, Institute of Chemistry - USP, University of São Paulo, Avenida Professor Lineu Prestes 748, Vila Universitaria, São Paulo, SP 05508-000, Brazil.
出版信息
Biomolecules. 2019 Dec 6;9(12):840. doi: 10.3390/biom9120840.
Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.
骨组织工程是一个不断变化、快速发展且高度跨学科的研究领域，科学家们试图尽可能地模拟天然骨结构，以促进骨愈合。细胞生物学的新见解，特别是间充质干细胞分化和信号转导，为骨再生带来了新的方法。基于多糖的新型支架和药物释放材料由于其广泛的可用性和良好的生物相容性而备受关注，可作为水凝胶和/或用于药物释放和组织工程的混合成分。本文综述了用于骨再生的多糖基系统的最新研究进展、未来展望。
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