Oral treatment of peritonitis in CAPD patients with two dosage regimens of ofloxacin.

Two open studies of oral treatment of peritonitis in CAPD patients with ofloxacin are described. The first study included 10 episodes of peritonitis treated with ofloxacin 400 mg followed by 200 mg daily for a total of seven days. In the second study of 18 peritonitis episodes, the treatment was ofloxacin 400 mg followed by 300 mg daily for a total of ten days. The cure rate was 50% in the first study and 83% in the second. There was significant accumulation of ofloxacin in the serum but the mean serum trough level with the second treatment regimen plateaued at 6 mg/l on day 10. Peritoneal effluent ofloxacin levels correlated well with the prevailing serum concentrations of the antibiotic and, except on day 1, the mean peritoneal effluent ofloxacin levels all exceeded 3 mg/l with the second dosing scheme. Side effects were mainly nausea and dizziness.