PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Am J Clin Nutr. 2020 Feb 1;111(2):329-339. doi: 10.1093/ajcn/nqz300.
Several studies have explored the role of human brown adipose tissue (BAT) in energy expenditure. However, the link between BAT and appetite regulation needs to be more rigorously examined.
We aimed to investigate the associations of BAT volume and 18F-fluordeoxyglucose (18F-FDG) uptake after a personalized cold exposure with energy intake and appetite-related sensations in young healthy humans.
A total of 102 young adults (65 women; age: 22.08 ± 2.17 y; BMI: 25.05 ± 4.93 kg/m 2) took part in this cross-sectional study. BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18F-FDG uptake were assessed by means of static 18F-FDG positron-emission tomography and computed tomography scans after a 2-h personalized exposure to cold. Energy intake was estimated via an objectively measured ad libitum meal and three nonconsecutive 24-h dietary recalls. Appetite-related sensations (i.e., hunger and fullness) were recorded by visual analog scales before and after a standardized breakfast (energy content = 50% of basal metabolic rate) and the ad libitum meal. Body composition was assessed by a whole-body DXA scan.
BAT volume and 18F-FDG uptake were not associated with quantified ad libitum energy intake (all P > 0.088), nor with habitual energy intake estimated from the 24-h dietary recalls (all P > 0.683). Lean mass was positively associated with both the energy intake from the ad libitum meal (β: 17.612, R2 = 0.213; P < 0.001) and the habitual energy intake (β: 16.052, R2 = 0.123; P = 0.001). Neither the interaction BAT volume × time elapsed after meal consumption nor that of BAT 18F-FDG uptake × time elapsed after meal consumption had any significant influence on appetite-related sensations after breakfast or after meal consumption (all P > 0.3).
Neither BAT volume, nor BAT 18F-FDG uptake after cold stimulation, are related to appetite regulation in young adults. These results suggest BAT plays no important role in the regulation of energy intake in humans.This trial was registered at clinicaltrials.gov as NCT02365129.
已有多项研究探讨了人类棕色脂肪组织（BAT）在能量消耗中的作用。然而，BAT 与食欲调节之间的联系仍需更严格地研究。
我们旨在研究个性化冷暴露后 BAT 体积和 18F-氟脱氧葡萄糖（18F-FDG）摄取与年轻健康人体能量摄入和食欲相关感觉之间的关联。
本横断面研究共纳入 102 名年轻成年人（65 名女性；年龄：22.08±2.17 岁；BMI：25.05±4.93 kg/m2）。通过静态 18F-FDG 正电子发射断层扫描和计算机断层扫描扫描，在 2 小时个性化冷暴露后评估 BAT 体积、BAT 18F-FDG 摄取和骨骼肌 18F-FDG 摄取。通过客观测量的随意餐和 3 次非连续 24 小时膳食回忆来估计能量摄入。在标准早餐（能量含量=基础代谢率的 50%）和随意餐后，通过视觉模拟量表记录与食欲相关的感觉（即饥饿感和饱腹感）。通过全身 DXA 扫描评估身体成分。
BAT 体积和 18F-FDG 摄取与定量随意能量摄入均无相关性（所有 P 值均>0.088），与 24 小时膳食回忆估计的习惯性能量摄入也无相关性（所有 P 值均>0.683）。瘦体重与随意餐的能量摄入（β：17.612，R2=0.213；P<0.001）和习惯性能量摄入（β：16.052，R2=0.123；P=0.001）均呈正相关。BAT 体积与餐后时间的交互作用和 BAT 18F-FDG 摄取与餐后时间的交互作用均对早餐后和餐后的食欲相关感觉无显著影响（所有 P 值均>0.3）。
冷刺激后 BAT 体积和 18F-FDG 摄取均与年轻人的食欲调节无关。这些结果表明 BAT 在人类能量摄入调节中不起重要作用。该试验在 clinicaltrials.gov 注册为 NCT02365129。
Zotero 插件
