Gerges Mina M, Godil Saniya S, Kacker Ashutosh, Schwartz Theodore H
Department of Neurosurgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York.
Department of Neurosurgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Oper Neurosurg (Hagerstown). 2020 Jul 1;19(1):E75-E81. doi: 10.1093/ons/opz380.
Brainstem lesions are challenging to manage, and surgical options have been controversial. Stereotactic radiosurgery (SRS) has been used for local control, but life-threatening toxicities from 0% to 9.5% have been reported. Several microsurgical approaches involving safe entry zones have been developed to optimize the exposure and minimize complications in different portions of the brainstem, but require extensive drilling and manipulation of neurovascular structures. With recent advancements, the endoscopic endonasal approach (EEA) can provide direct visualization of ventral brainstem. No case has been reported of EEA to remove a brainstem metastasis.
We present an illustrative case of a 68-yr-old female with metastatic colon cancer who presented with 2.8 × 2.7 × 2.1 cm (7.9 cm3) heterogeneously enhancing, right ventral pontine lesion with extensive edema. She underwent endoscopic endonasal transclival approach, and gross total resection of the lesion was achieved.
The endoscopic approach may offer certain advantages for removal of ventral brainstem lesions, as it can provide direct visualization of important neurovascular structures, especially, if the lesion displaces the tracts and comes superficial to the pial surface.
脑干病变的治疗具有挑战性,手术方案一直存在争议。立体定向放射外科(SRS)已用于局部控制,但据报道有0%至9.5%的危及生命的毒性反应。为了优化暴露并将脑干不同部位的并发症降至最低,已经开发了几种涉及安全进入区域的显微手术方法,但需要广泛钻孔和操作神经血管结构。随着最近的进展,内镜鼻内入路(EEA)可以直接观察脑干腹侧。尚未有关于EEA切除脑干转移瘤的病例报道。
我们展示了一例68岁转移性结肠癌女性患者的病例,其右侧腹侧脑桥有一个2.8×2.7×2.1厘米(7.9立方厘米)的不均匀强化病灶,并伴有广泛水肿。她接受了内镜鼻内经斜坡入路,实现了病灶的全切除。
内镜入路在切除脑干腹侧病变方面可能具有一定优势,因为它可以直接观察重要的神经血管结构,特别是当病变推移神经束并位于软膜表面浅层时。