奥芬那君治疗肝硬化患者肌肉痉挛的随机研究。
Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study.
作者信息
Abd-Elsalam Sherief, Ebrahim Shaimaa, Soliman Shaimaa, Alkhalawany Walaa, Elfert Asem, Hawash Nehad, Elkadeem Mahmoud, Badawi Rehab
机构信息
Department of Tropical medicine, Faculty of Medicine, Tanta University.
Department of Public health, Menofia University, Egypt.
出版信息
Eur J Gastroenterol Hepatol. 2020 Aug;32(8):1042-1045. doi: 10.1097/MEG.0000000000001622.
OBJECTIVE
Many patients of liver cirrhosis are complaining of muscle cramps, which are annoying to them. There is no effective treatment for muscle cramps in cirrhotic patients till now. This study purposed to evaluate efficacy and safety of orphenadrine in the treatment of muscle cramps in cirrhotic patients.
METHODS
One hundred and twenty four patients who had muscle cramps three or more times weekly were included. They were divided into two arms: 62 patients administrated orphenadrine and 62 administrated placebo. They were followed up till 2 weeks after the end of therapy. Muscle cramps were evaluated using questionnaire as regards severity, duration, and frequency. Also, side effects of orphenadrine were recorded.
RESULTS
Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo. Few side effects were recorded in the form of dry mouth, drowsiness, and nausea.
CONCLUSION
Orphenadrine is considered as promising safe drug for treatment of muscle cramps associated with liver cirrhosis.
目的
许多肝硬化患者抱怨肌肉痉挛，这让他们很苦恼。目前对于肝硬化患者的肌肉痉挛尚无有效的治疗方法。本研究旨在评估奥芬那君治疗肝硬化患者肌肉痉挛的疗效和安全性。
方法
纳入124例每周出现3次或以上肌肉痉挛的患者。他们被分为两组：62例患者服用奥芬那君，62例患者服用安慰剂。随访至治疗结束后2周。使用问卷对肌肉痉挛的严重程度、持续时间和频率进行评估。同时，记录奥芬那君的副作用。
结果
与安慰剂相比，奥芬那君治疗1个月后，肌肉痉挛的频率、持续时间和疼痛评分均有显著改善。记录到的副作用较少，表现为口干、嗜睡和恶心。
结论
奥芬那君被认为是治疗与肝硬化相关的肌肉痉挛的一种有前景的安全药物。
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