Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Vídeňská 800, 140 59 Prague 4, Czech Republic.
Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.
Eur Heart J Cardiovasc Pharmacother. 2020 Nov 1;6(6):384-393. doi: 10.1093/ehjcvp/pvz082.
Hypertensive disorders are the most common medical complications in the peripartum period associated with a substantial increase in morbidity and mortality. Hypertension in the peripartum period may be due to the continuation of pre-existing or gestational hypertension, de novo development of pre-eclampsia or it may be also induced by some drugs used for analgesia or suppression of postpartum haemorrhage. Women with severe hypertension and hypertensive emergencies are at high risk of life-threatening complications, therefore, despite the lack of evidence-based data, based on expert opinion, antihypertensive treatment is recommended. Labetalol intravenously and methyldopa orally are then the two most frequently used drugs. Short-acting oral nifedipine is suggested to be used only if other drugs or iv access are not available. Induction of labour is associated with improved maternal outcome and should be advised for women with gestational hypertension or mild pre-eclampsia at 37 weeks' gestation. This position paper provides the first interdisciplinary approach to the management of hypertension in the peripartum period based on the best available evidence and expert consensus.
高血压疾病是围产期最常见的医学并发症,与发病率和死亡率的大幅增加有关。围产期高血压可能是由于先前存在的或妊娠高血压的持续存在,也可能是新出现的子痫前期,或者也可能是由于一些用于镇痛或抑制产后出血的药物引起的。患有严重高血压和高血压急症的妇女有发生危及生命的并发症的高风险,因此,尽管缺乏基于证据的循证数据,但根据专家意见,建议进行降压治疗。静脉注射拉贝洛尔和口服甲基多巴是最常使用的两种药物。如果其他药物或静脉通路不可用,则建议仅使用短效口服硝苯地平。对于妊娠高血压或 37 孕周轻度子痫前期的妇女,建议引产,以改善母婴结局。本立场文件基于现有最佳证据和专家共识,首次提供了围产期高血压管理的跨学科方法。