正常人及糖耐量受损者的血浆 GIP 与 GLP-1 水平的关系。

The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance.

机构信息

Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide Medical School, The University of Adelaide, Level 5 Adelaide Health and Medical Sciences Building, Cnr North Tce and George St, Adelaide, SA, 5005, Australia.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, 5005, Australia.

出版信息

Acta Diabetol. 2020 May;57(5):583-587. doi: 10.1007/s00592-019-01461-z. Epub 2019 Dec 17.

DOI:10.1007/s00592-019-01461-z

PMID:31848710

Abstract

AIMS

Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GIP has the dominant role. It is uncertain whether there is a relationship between GIP and GLP-1 secretion. We aimed to evaluate the relationship between plasma GIP and GLP-1 responses to a 75-g oral glucose load in individuals with normal (NGT) and impaired glucose tolerance (IGT).

METHODS

One hundred healthy subjects had measurements of blood glucose, serum insulin, plasma GIP and GLP-1 concentrations for 240 min after a 300 mL drink containing 75 g glucose.

RESULTS

Fifty had NGT and 41 IGT; 9 had type 2 diabetes and were excluded from analysis. In both groups, there were increases in plasma GIP and GLP-1 following the glucose drink, with no difference in the magnitude of the responses between t = 0-240 min. There was a weak relationship between the iAUC for GIP and GLP-1 in the combined (r = 0.23, P = 0.015) and in the IGT (r = 0.34, P = 0.01), but not in the NGT (r = 0.15, P = 0.14) group.

CONCLUSIONS

There is a weak relationship between oral glucose-induced GIP and GLP-1 secretions in non-diabetic subjects.

摘要

目的

葡萄糖依赖性胰岛素多肽（GIP）主要从近端小肠释放，胰高血糖素样肽-1（GLP-1）从更远端的小肠和结肠释放。在过去，它们对肠促胰岛素效应的相对重要性一直存在争议，尽管现在似乎 GIP 起主要作用。尚不确定 GIP 和 GLP-1 分泌之间是否存在关系。我们旨在评估 75g 口服葡萄糖负荷后，血糖正常（NGT）和糖耐量受损（IGT）个体的血浆 GIP 和 GLP-1 反应之间的关系。

方法

100 名健康受试者在饮用 300ml 含 75g 葡萄糖的饮料后 240 分钟内测量血糖、血清胰岛素、血浆 GIP 和 GLP-1 浓度。

结果

50 人有 NGT，41 人有 IGT；9 人患有 2 型糖尿病，被排除在分析之外。在两组中，在葡萄糖饮料后，血浆 GIP 和 GLP-1 均增加，在 t=0-240 分钟之间，反应幅度没有差异。在联合组（r=0.23，P=0.015）和 IGT 组（r=0.34，P=0.01）中，GIP 和 GLP-1 的 iAUC 之间存在弱相关性，但在 NGT 组（r=0.15，P=0.14）中则没有。