帕金森病和进行性核上性麻痹患者的光学相干断层扫描。
Optical coherence tomography of patients with Parkinson's disease and progressive supranuclear palsy.
机构信息
Division of Neurology, University of British Columbia, Vancouver, BC, Canada; Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, NY, USA; Department of Neurology, Kings County Hospital, Brooklyn, NY, USA.
Neuro-ophthalmology, Department of Ophthalmology, University of British Columbia, Vancouver, BC, Canada; Vista Klinik, Vista Diagnostics and Laser Vista, Binningen, Switzerland.
出版信息
Clin Neurol Neurosurg. 2020 Feb;189:105635. doi: 10.1016/j.clineuro.2019.105635. Epub 2019 Dec 9.
OBJECTIVES
To determine if Parkinson's disease (PD) and progressive supranuclear palsy (PSP) differed on retinal measurements using optical coherence tomography (OCT).
PATIENTS AND METHODS
In a prospective, controlled, cross-sectional cohort study, we recruited patients with PD or PSP for more than three years, as well as control subjects. We measured peripapillary retinal nerve fiber layer (RNFL) thickness and macular volume using spectral-domain OCT. The association between these OCT measures and the disease characteristics of duration and disability were examined using a linear mixed effect model.
RESULTS
We analyzed eyes from n = 12 PD patients, n = 11 PSP patients, and n = 12 control subjects. RNFL thickness was reduced in eyes from patients with PSP, but there were no differences in macular volume between groups. RNFL thickness and macular volume were not significantly different between eyes from patients with PD and controls. Worse disability was associated with reduced macular volumes.
CONCLUSION
PSP but not PD is associated with thinning of the peripapillary RNFL when symptoms have been present for more than three years.
目的
利用光学相干断层扫描（OCT）确定帕金森病（PD）和进行性核上性麻痹（PSP）在视网膜测量方面是否存在差异。
患者和方法
在一项前瞻性、对照、横断面队列研究中，我们招募了 PD 或 PSP 患者超过三年，以及对照组。我们使用频域 OCT 测量了视盘周围视网膜神经纤维层（RNFL）厚度和黄斑体积。使用线性混合效应模型检查这些 OCT 测量值与疾病持续时间和残疾程度之间的相关性。
结果
我们分析了 n = 12 例 PD 患者、n = 11 例 PSP 患者和 n = 12 例对照组的眼睛。PSP 患者的视盘周围 RNFL 厚度变薄，但各组之间黄斑体积无差异。PD 患者的眼睛与对照组的 RNFL 厚度和黄斑体积无显著差异。更严重的残疾与黄斑体积减少相关。
结论
当症状出现超过三年时，PSP 而不是 PD 与视盘周围 RNFL 变薄有关。
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