Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA.
Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan, PR 00926, USA.
Mar Drugs. 2019 Dec 19;18(1):5. doi: 10.3390/md18010005.
The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998-2013 reviews of this series. Research in marine pharmacology during 2014-2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014-2015, the marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.
2014 年至 2015 年的海洋药理学文献系统评价是按照本系列 1998-2013 年的评价方法完成的。在 2014-2015 年期间，来自 43 个国家的研究人员报告了海洋药理学方面的研究，描述了 301 种海洋化合物的临床前药理学的新发现。这些观察结果包括 133 种海洋天然产物、85 种具有抗糖尿病和抗炎活性的海洋化合物、以及影响免疫系统和神经系统的化合物，以及 83 种具有多种作用机制的海洋化合物，这些化合物可能在进一步研究后为新的药理学类别做出贡献。因此，在 2014-2015 年，海洋天然产物药理学研究为海洋药物学研究提供了新的药理学和新的先导化合物，继续为全球正在进行的替代治疗方法研究做出贡献，以治疗许多疾病类别。
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