AVATAR：眼介入放射治疗后视力预测分析。
AVATAR: Analysis for Visual Acuity Prediction After Eye Interventional Radiotherapy.
机构信息
U.O.C. Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
出版信息
In Vivo. 2020 Jan-Feb;34(1):381-387. doi: 10.21873/invivo.11784.
AIM
The aim of this study was to detect clinical factors predictive of loss of visual acuity after treatment in order to develop a predictive model to help identify patients at risk of visual loss.
PATIENTS AND METHODS
This was a retrospective review of patients who underwent interventional radiotherapy (brachytherapy) with Ru plaque for primary uveal melanoma. A predictive nomogram for visual acuity loss at 3 years from treatment was developed.
RESULTS
A total of 152 patients were selected for the study. The actuarial probability of conservation of 20/40 vision or better was 0.74 at 1 year, 0.59 at 3 years, and 0.54 at 5 years after treatment. Factors positively correlated with loss of visual acuity included: age at start of treatment (p=0.004) and longitudinal basal diameter (p=0.057), while distance of the posterior margin of the tumor from the foveola was inversely correlated (p=0.0007).
CONCLUSION
We identified risk factors affecting visual function and developed a predictive model and decision support tool (AVATAR nomogram).
目的
本研究旨在发现治疗后视力丧失的预测因素，以制定预测模型，帮助识别有视力丧失风险的患者。
患者与方法
这是对接受放射性碘 125 粒子近距离放疗（腔内近距离放疗）治疗原发性脉络膜黑色素瘤的患者进行的回顾性研究。制定了治疗后 3 年视力丧失的预测列线图。
结果
共选择了 152 名患者进行研究。治疗后 1 年、3 年和 5 年时，20/40 或更好视力保留的累积概率分别为 0.74、0.59 和 0.54。与视力丧失正相关的因素包括：治疗开始时的年龄（p=0.004）和纵向基底直径（p=0.057），而肿瘤后极距黄斑的距离呈负相关（p=0.0007）。
结论
我们确定了影响视觉功能的危险因素，并制定了预测模型和决策支持工具（AVATAR 列线图）。
Zotero 插件