COMPASS-ND神经退行性疾病研究中的衰弱患病率。
Frailty Prevalence in the COMPASS-ND Study of Neurodegenerative Disorders.
作者信息
Burt Jacqueline R, Godin Judith, Filion Josée, Montero-Odasso Manuel, Rockwood Kenneth, Andrew Melissa K, Camicioli Richard
机构信息
Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
出版信息
Can Geriatr J. 2019 Dec 30;22(4):205-212. doi: 10.5770/cgj.22.392. eCollection 2019 Dec.
BACKGROUND
Frailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures.
METHODS
Data from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status according to FI and FP criteria were ascertained for each participant.
RESULTS
81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail.
CONCLUSION
The presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.
背景
衰弱的特征是对不良健康结局的易感性增加。神经退行性疾病（NDD）中衰弱的患病率很大程度上未知。衰弱和NDD的症状重叠，这使得一些衰弱评估工具中的同义反复受到质疑。我们的目标是：1）构建一个独立于NDD症状的衰弱指数（FI），以及2）使用衰弱表型（FP）和构建的FI作为测量方法，估计一个广泛的NDD队列中的衰弱患病率。
方法
评估来自加拿大COMPASS-ND队列研究的数据对构建FI的适用性。确定每位参与者根据FI和FP标准的衰弱状态。
结果
为FI选择了81个项目。在该队列（150名参与者；46%为女性；平均年龄73.6±7.0；10个NDD亚组）中，根据FI和FP分别确定11%和14%的参与者存在衰弱。估计值之间的差异不显著。FP将大多数参与者（84%）归类为衰弱前期。
结论
衰弱因素的存在，无论它们是否是NDD的一部分，都可能影响健康状况。鉴于FP将很大比例的队列参与者识别为衰弱前期或衰弱，在NDD背景下识别衰弱可能是值得的。
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