硫酸铜催化甲苯与异腈的串联C(sp)-H插入环化反应以形成吲哚。
CuSO-Catalyzed Tandem C(sp)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles.
作者信息
Shan Xiang-Huan, Wang Mei-Mei, Tie Lin, Qu Jian-Ping, Kang Yan-Biao
机构信息
Department of Chemistry , University of Science and Technology of China , Hefei , Anhui 230026 , China.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering , Nanjing Tech University , Nanjing 211816 , China.
出版信息
Org Lett. 2020 Jan 17;22(2):357-360. doi: 10.1021/acs.orglett.9b03751. Epub 2019 Dec 30.
A CuSO-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of -aryl indoles from isonitriles.
描述了一种硫酸铜催化的甲苯衍生物与异腈的串联苄基C-H插入环化反应。天然丰富的盐硫酸铜用作低成本的无配体氧化还原催化剂。该反应提供了一种从异腈实际模块化合成β-芳基吲哚的方法。
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