Khalil Ibrahim, Yehye Wageeh A, Etxeberria Alaitz Etxabide, Alhadi Abeer A, Dezfooli Seyedehsara Masoomi, Julkapli Nurhidayatullaili Binti Muhd, Basirun Wan Jefrey, Seyfoddin Ali
Nanotechnology and Catalysis Research Centre (NANOCAT), Institute for Advanced Studies, University of Malaya, Kuala Lumpur 50603, Malaysia.
Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 0627, New Zealand.
Antioxidants (Basel). 2019 Dec 26;9(1):24. doi: 10.3390/antiox9010024.
Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.
抗氧化剂与自由基相互作用，终止不良连锁反应并将其转化为无害产物。因此，抗氧化剂可将氧化应激降至最低，并在治疗自由基诱导的疾病中发挥关键作用。然而，天然和/或合成抗氧化剂的有效性有限，这是由于它们吸收不良、难以穿过细胞膜以及在递送过程中降解，因此导致其生物利用度有限。为了解决这些问题，与纳米颗粒共价连接、包裹在纳米凝胶、中空颗粒中或封装到不同来源的纳米颗粒中的抗氧化剂已被用于提供更好的稳定性、逐步和持续释放、生物相容性以及具有优异抗氧化特性的抗氧化剂的靶向递送。本综述旨在批判性地评估纳米颗粒作为抗氧化剂递送载体的最新科学评估，以及它们在高效和增强抗氧化活性方面的贡献。
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