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严重创伤并发真菌感染和骨结核

Complication of massive trauma by fungal infection and bone tuberculosis.

作者信息

Elzein Fatehi, Mohammed Nazik, Arafah Maria, Albarrag Ahmed, Habib Rabea, Faqehi Aqeel

机构信息

Infectious Diseases Unit, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia.

Department of Pathology, King Saud University, Riyadh, Saudi Arabia.

出版信息

Med Mycol Case Rep. 2019 Dec 9;27:4-7. doi: 10.1016/j.mmcr.2019.12.006. eCollection 2020 Mar.

Abstract

We report a middle aged man who was admitted with severe necrotising fasciitis following a motor vehicle accident (MVA). Histopathology of the excised tissue suggested mucormycosis while a bone tissue culture revealed fully sensitive . He received intravenous liposomal amphotericin B combined with multiple surgical debridements and ended with right shoulder disarticulation. In addition he completed a nine months course of anti-tuberculosis treatment. He remained stable one year following his admission. We believe that trauma contributed to both conditions by direct inoculation of fungal spores and through immunological reactivation of old healed tuberculosis focus. This case highlights the importance of considering diagnosis of invasive fungal infections following MVA.

摘要

我们报告了一名中年男性,他在机动车事故(MVA)后因严重坏死性筋膜炎入院。切除组织的组织病理学提示毛霉菌病,而骨组织培养显示完全敏感。他接受了静脉注射脂质体两性霉素B联合多次手术清创,最终进行了右肩关节离断术。此外,他完成了九个月的抗结核治疗疗程。入院一年后他病情保持稳定。我们认为,创伤通过直接接种真菌孢子以及通过旧的愈合结核病灶的免疫激活促成了这两种情况。该病例突出了考虑MVA后侵袭性真菌感染诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f5/6926242/4c4324dd5b1f/gr1.jpg

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