原发性甲状旁腺功能亢进患者的甲状旁腺重量与高密度脂蛋白水平相关。
Parathyroid gland weight is associated with high density lipoprotein levels in patients with primary hyperparathyroidism.
作者信息
Dayyeni Aseel Al, Mahdi Amar, He Yuling, Trooskin Stanley Z, Meng Lingqiong, Wang Xiangbing
机构信息
Divisions of Endocrinology, Departments of Medicine, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Divisions of General Surgery, Departments of Surgery, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
出版信息
J Clin Transl Endocrinol. 2019 Nov 26;19:100213. doi: 10.1016/j.jcte.2019.100213. eCollection 2020 Mar.
OBJECTIVE
To investigate the relationship between parathyroid gland weight and high-density lipoprotein (HDL) levels in patients with primary hyperparathyroidism (PHPT).
METHODS
In this retrospective case control study, we reviewed 329 PHPT patients aged from 20 to 85 years who had a parathyroidectomy at Robert Wood Johnson University Hospital. The patients were divided into 5 quintiles according to their parathyroid gland weight: 68 patients had a parathyroid gland weight <0.3 g, 66 patients had a gland weight 0.3-0.45 g, 67 patients had a gland weight 0.45-0.7 g, 63 patients had a gland weight 0.7-1.25 g, and 65 patients had a gland weight ≥1.25 g.
RESULTS
Body Mass Index (BMI) trended to be higher across the quintiles of parathyroid gland weight (P = 0.003). Serum calcium and PTH levels were significantly increased across parathyroid gland quintiles (p < 0.0001). HDL levels tended to be lower across the increasing quintiles of parathyroid gland weight (P = 0.01). There was a negative relationship between log parathyroid gland weight and HDL in patients with PHPT in a simple linear regression (r = -0.160, P = 0.003). The negative association remained significant after adjustment for age and BMI (r = -0.114, P = 0.039). Furthermore, parathyroid gland weight was significantly associated with levels of triglyceride (r = 0.126, P = 0.02), but this relationship lost its significance after adjustment for age and BMI (r = 0.082, P ˃ 0.05).
CONCLUSIONS
PHPT patients with heavier parathyroid glands tended to have higher BMI and lower HDL levels.
目的
探讨原发性甲状旁腺功能亢进症（PHPT）患者甲状旁腺重量与高密度脂蛋白（HDL）水平之间的关系。
方法
在这项回顾性病例对照研究中，我们回顾了329例年龄在20至85岁之间、于罗伯特·伍德·约翰逊大学医院接受甲状旁腺切除术的PHPT患者。根据甲状旁腺重量将患者分为5个五分位数组：68例患者甲状旁腺重量<0.3g，66例患者甲状旁腺重量为0.3 - 0.45g，67例患者甲状旁腺重量为0.45 - 0.7g，63例患者甲状旁腺重量为0.7 - 1.25g，65例患者甲状旁腺重量≥1.25g。
结果
甲状旁腺重量五分位数组的体重指数（BMI）呈上升趋势（P = 0.003）。甲状旁腺五分位数组的血清钙和甲状旁腺激素（PTH）水平显著升高（p < 0.0001）。随着甲状旁腺重量五分位数的增加，HDL水平呈下降趋势（P = 0.01）。在简单线性回归中，PHPT患者的甲状旁腺重量对数与HDL之间存在负相关（r = -0.160，P = 0.003）。在调整年龄和BMI后，这种负相关仍然显著（r = -0.114，P = 0.039）。此外，甲状旁腺重量与甘油三酯水平显著相关（r = 0.126，P = 0.02），但在调整年龄和BMI后，这种关系失去了显著性（r = 0.082，P > 0.05）。
结论
甲状旁腺较重的PHPT患者往往BMI较高且HDL水平较低。
Zotero 插件